Creating Biomedical Technologies to Improve Health



Science Highlights • June 27, 2016
In 2011, researchers supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the National Institutes of Health, developed a technique, called phage-assisted continuous evolution (or PACE), that rapidly generates proteins with new, sought-after properties and therapeutic potential. Originally conceived as a tool for pharmaceutical development, the researchers now have shown its potential in protecting crops from insects.

Grantee News • June 23, 2016

A new phase 1 clinical trial evaluated the differences between pre-operative prone and supine MRI exams in 12 women undergoing lumpectomy for breast cancer. Researchers demonstrated that considerable deformity of the breast and tumor position occurs when patients are imaged in the prone position. Read more at Medical Xpress.

Grantee News • June 17, 2016

A new technique repairs large bone defects in the head and face by using lab-grown living bone, tailored to the patient. This is the first time researchers have grown living bone grown to precisely replicate the original anatomical structure, using autologous stem cells derived from a small sample of the recipient's fat. Read more at Columbia Engineering.

Grantee News • June 17, 2016

Observations of how T-cell receptors reposition during an immune response could help scientists better understand how to regulate the immune system’s activity to treat autoimmune diseases, infections or even cancer. Read more at Salk News.

Grantee News • June 9, 2016

In its third year, eMerge Americas brings together technology experts, enthusiasts, and investors from all over the world. Held this year in Miami, it included NIBIB-funded scientists demonstrating their neural-enabled prosthetic arm that is designed to give sensation back to an amputee. Read more and watch the video at CBS Miami.

Science Highlights • June 9, 2016
Knowing the exact number of molecules located at specific junctures in cells can be a critical measure of health as well as disease. For example, abnormally high numbers of growth factor receptors on cells can be an indication of cancerous and precancerous states; specific proteins located at the junction where neurons connect in the brain may affect brain function as they accumulate or disperse. Now, a simplified method known as qPAINT uses the blinking pattern of the light that marks each molecule, to find, count, and study individual molecules that are just a few nanometers apart.
Science Highlights • June 6, 2016

An international team of researchers funded in part by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the National Institutes of Health, has discovered distinct roles for two types of vessels within the bone marrow, an understanding that could help improve stem cell transplants and create better interventions for diseases like leukemia. One type of vessel preserves a pool of stem cells, while the other type promotes stem cell differentiation into new blood cells and the migration of the new blood cells out of the bone marrow.

Grantee News • June 2, 2016

Physicians have long used magnetic resonance imaging (MRI) to detect cancer, but results of a new study describe the potential use of restriction spectrum imaging (RSI) as an imaging biomarker that enhances the ability of MRI to differentiate aggressive prostate cancer from low-grade or benign tumors and guide treatment and biopsy. Read more at UC San Diego Health.

Science Highlights • June 1, 2016
“Base Editor” corrects point mutations more reliably 
Grantee News • May 27, 2016

The world's most advanced light microscopes allow us to see single molecules, proteins, viruses and other very small biological structures -- but even the best microscopes have their limits. Now scientists are pushing the limits of a technique called super-resolution microscopy, opening potential new pathways to illuminating, for example, individual cell processes in living tissue at unprecedented resolutions. Read more at Colorado State University SOURCE.