Biochemical Engineering

This program supports the design, development, and demonstration of biochemical technologies for biomedical intervention.


This program focuses on engineering new biochemical materials, sensors, actuators, and other parts and modules to interface and communicate with human biology and engineered systems for biomedical intervention. These parts and modules act as biotransducers to convert chemical energy to biological action. Projects should be directed toward overcoming a technological challenge that limits biomedical adoption. This program encourages projects that use a design-build-test approach.

Examples of biochemical parts and modules include but are not limited to:

  • nucleases for genome editors
  • toehold switches for synthetic genetic circuits
  • transmembrane CARs for T-cells
  • disordered protein compartments for intracellular communication
  • polymeric hydrogels for therapeutic devices
  • nano-structured metal oxide surfaces for implant infection mitigation
  • engineered viruses, exosomes, and nanoparticles for therapeutic agent delivery
  • genome editors for DNA sequence manipulation

Additional emphasis

Furthermore, this program focuses on the development of mathematical and computational methods, the development of screening and processing tools, and the discovery of design principles as key components in the design, build, and test methodology to engineer relevant biochemical modules.


The development of integrated systems is supported by the Bionic Systems, Robotic Systems, Synthetic Biological Systems, and Adaptive Biomaterial Systems programs.

Grant Number Project Title Principal Investigator Institution
1-DP2-EB024377-01 A New Paradigm in Nanomedicine: can structural interiors of nanoparticles regulate cellular delivery? Cecilia Leal University of Illinois at Urbana-Champaign
1-DP2-EB026265-01 Mineralomics: Designing mineral based therapeutics to control and direct cell function Akhilesh Gaharwar Texas Engineering Experiment Station
1-DP2-EB025760-01 Using Cell Priming and Telecommunications Modeling to Enhance Gene Delivery for Stem Cell Therapies Angela Pannier University of Nebraska Lincoln
5-R00-EB021030-05 Engineering Synthetic Receptor Systems That Can Detect Specific Cell-Cell Contact Leonardo Morsut University of Southern California
5-R21-EB024733-03 Biosensor for Non-Invasive Glucose Detection in Exhaled Breath Condensates Jacqueline Linnes Purdue University
5-R21-EB024748-03 Artificial Stromal Cell for Hematopoietic Stem Cell Expansion Keyue Shen University of Southern California
5-R44-EB027611-03 An Automated Device for High Yield Mesenchymal Stem Cell Extraction Lotien Huang Cg Scientific, Inc.
5-R01-EB023287-03 MSC Encapsulation with Thin Gel Coating David Mooney Harvard University
5-R01-EB023294-04 Intravascular Chemical Sensors with Improved Biocompatiblity/Performance via Nitric Oxide Release Mark Meyerhoff University of Michigan at Ann Arbor
5-R01-EB023114-04 Direct reprogramming of epidermal cells to neural crest derivatives for cell therapies Stelios Andreadis State University of New York at Buffalo