Biomaterial Interfaces

This program supports the development and demonstration of biomaterial interfaces. These modular platform technologies are designed to manipulate and interface with biology to enable new paradigms of clinical intervention for human health.


This program focuses on engineering new prototype biomaterial interfaces to mediate human biology for clinical purposes. These technologies are biochemical, biomechanical, bioelectric, biomagnetic, bioacoustic, and biophotonic transducers designed to interconvert energy and biological action. Projects should be directed toward overcoming a technological challenge that limits biomedical adoption. This program encourages projects that use a design-build-test approach.

Examples of technologies include but are not limited to:

  • nucleases for genome editors for therapeutic DNA editing
  • nano-structured metal oxide surfaces and polymeric hydrogels for implant infection mitigation
  • exosomes and liposomes for therapeutic agent delivery
  • electrically conductive and mechano-sensitive scaffolds for repairing tissue
  • magnetic and acoustic nanoparticles for ablating cells and tissues
  • plasmonic nanorods for tissue suturing

Additional emphasis

Furthermore, this program focuses on the discovery of design principles as key components in the design, build, and test methodology to engineer relevant biomaterials interfaces.

Grant Number Project Title Principal Investigator Institution
1-DP2-EB024377-01 A New Paradigm in Nanomedicine: can structural interiors of nanoparticles regulate cellular delivery? Cecilia Leal University of Illinois at Urbana-Champaign
1-DP2-EB025760-01 Using Cell Priming and Telecommunications Modeling to Enhance Gene Delivery for Stem Cell Therapies Angela Pannier University of Nebraska Lincoln
1-DP2-EB026265-01 Mineralomics: Designing mineral based therapeutics to control and direct cell function Akhilesh Gaharwar Texas Engineering Experiment Station
5-R01-EB023287-03 MSC Encapsulation with Thin Gel Coating David Mooney Harvard University
5-R01-EB023294-04 Intravascular Chemical Sensors with Improved Biocompatiblity/Performance via Nitric Oxide Release Mark Meyerhoff University of Michigan at Ann Arbor
5-R01-EB023114-04 Direct reprogramming of epidermal cells to neural crest derivatives for cell therapies Stelios Andreadis State University of New York at Buffalo
1-R15-EB027449-01A1 Diamond-like Carbon Thin Films for Anti-fog Lens Coating in Laparoscopy Jacqueline Johnson University of Tennessee Space Institute
5-R01-EB022641-04 Supramolecular Bioorthogonal Nanozymes for Targeted Activation of Therapeutics Vincent Rotello University of Massachusetts Amherst
5-R03-EB027299-02 Electrochemical approach for reliable cardiac output measurements Madhavan Raghavan University of Iowa
5-R21-EB027855-02 Mirror image DNA circuitry for complex microRNA analysis in live cells Jonathan Sczepanski Texas A&M University