Biomaterial Interfaces

This program supports the development and demonstration of biomaterial interfaces. These modular platform technologies are designed to manipulate and interface with biology to enable new paradigms of clinical intervention for human health.


This program focuses on engineering new prototype biomaterial interfaces to mediate human biology for clinical purposes. These technologies are biochemical, biomechanical, bioelectric, biomagnetic, bioacoustic, and biophotonic transducers designed to interconvert energy and biological action. Projects should be directed toward overcoming a technological challenge that limits biomedical adoption. This program encourages projects that use a design-build-test approach.

Examples of technologies include but are not limited to:

  • nucleases for genome editors for therapeutic DNA editing
  • nano-structured metal oxide surfaces and polymeric hydrogels for implant infection mitigation
  • exosomes and liposomes for therapeutic agent delivery
  • electrically conductive and mechano-sensitive scaffolds for repairing tissue
  • magnetic and acoustic nanoparticles for ablating cells and tissues
  • plasmonic nanorods for tissue suturing

Additional emphasis

Furthermore, this program focuses on the discovery of design principles as key components in the design, build, and test methodology to engineer relevant biomaterials interfaces.


Small Business Initiatives webinar:

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Grant Number Project Title Principal Investigator Institution
5-R01-EB024601-04 Minimally-Invasive Metabolite Monitoring Systems for in vitro and in vivo Disease Models Mike Mcshane Texas Engineering Experiment Station
5-R01-EB026344-04 Multivalent Nano-conjugates for Targeted Penetration of and Delivery to Dense Extracellular Matrices Paula Hammond Massachusetts Institute of Technology
5-R01-EB017742-08 Autonomous Grippers in the Gastrointestinal Tract Florin Selaru Johns Hopkins University
5-R21-EB028519-03 Modeling atypical hemolytic uremic syndrome with hydrogel-based microvasculature-on-chip technologies Yongzhi Qiu Emory University
5-R21-EB029261-02 The Role of C-Flip in Mediating Pro-Survival Macrophages in the Foreign Body Response Stephanie Bryant University of Colorado
5-R01-EB025596-04 A 3D human tissue-engineered lung model to study immune responses to Respiratory Syncytial Virus Susan Kovats Oklahoma Medical Research Foundation
1-R21-EB032019-01 Multi-target suppression of pro-inflammatory cytokines using engineered targeted ribonucleases Gerald Wilson University of Maryland Baltimore
5-R01-EB000244-42 A new high-throughput gastrointestinal tract explant platform for drug formulation discovery and metabolic disease modulation Robert Langer Massachusetts Institute of Technology
1-R15-EB031388-01 Nucleic Acid Nanoparticle-based Monoclonal Antibody Mimics Emil Khisamutdinov Ball State University
1-R21-EB031597-01 Design and evaluation of a multivalent nanobody construct for prevention or treatment of SARS-CoV-2 Julie Champion Georgia Institute of Technology