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Biomaterials and Biomolecular Constructs

This program supports the development of biomaterials and biomolecular constructs to elicit a broadly applied biomedically relevant effect across a spectrum of diagnostic, therapeutic, imaging, and interventional applications.

Emphasis is on engineering functionality and issues surrounding biocompatibility of biomaterials and biomolecular constructs. Function could be derived from the static or dynamic properties of materials and based on biochemical, electromagnetic, mechanical, and/or tribological properties, for example.

Additional emphasis
The biomaterials and biomolecular constructs may be engineered to further enable technologies that are relevant to other NIBIB-supported program areas including but not limited to:

The biomaterials and biomolecular constructs may be components of control systems, such as:

  • delivery vehicles (liposomes, DNA nanoparticles, virus-like particles, metallic nanoparticles, micelles, dendrimers, etc.) for the targeted control of active agents
  • surface-modified substrates for microfluidic platforms
  • toehold switches for synthetic genetic circuits
  • nucleases for genome editing machinery

Furthermore, this program supports the development of control systems (e.g., genome editing machinery, synthetic genetic circuits, microfluidics, etc.) designed to engineer biomaterials and biomolecular constructs.

Lastly, this program supports the development of analytical tools to interrogate biomaterials and biomolecular constructs as related to their design, development, and initial validation.

The development of imaging probes is supported by the NIBIB Molecular Probes and Imaging Agents program.

Grant Number Project Title Principal Investigator Institution
1-DP2-EB024377-01 A New Paradigm in Nanomedicine: can structural interiors of nanoparticles regulate cellular delivery? Cecilia Leal University of Illinois at Urbana-Champaign
1-DP2-EB025760-01 Using Cell Priming and Telecommunications Modeling to Enhance Gene Delivery for Stem Cell Therapies Angela Pannier University of Nebraska Lincoln
1-F31-EB025735-01A1 Biodegradable Polymer Surgical Sealant with Increased Adhesion and Reduced Inflammation John Daristotle Univ of Maryland, College Park
1-F31-EB027579-01 Engineering immune polyelectrolyte multilayers to study the effect of toll-like receptor agonists on immune response Michelle Bookstaver Univ of Maryland, College Park
1-F32-EB023796-01A1 Remote Control of Enzymes and Cellular Metabolism Ryan Riskowski Colorado State University
5-F32-EB024391-02 Engineered Sense and Response Circuits for Stem Cell-Based Tissue Regeneration and Repair Jonathan Brunger University of California, San Francisco
1-K99-EB023979-01A1 Non-viral delivery of CRISPR/Cas9 for targeted gene replacement Christopher Nelson Duke University
5-P41-EB001046-15 Integrated Technologies for Polymeric Biomaterials, RESBIO Joachim Kohn Rutgers, The State Univ of N.J.
5-R00-EB016690-05 Role of cerebrospinal fluid dynamics in brain drug delivery Jay Sy Rutgers, The State Univ of N.J.
5-R00-EB021030-04 Engineering Synthetic Receptor Systems That Can Detect Specific Cell-Cell Contact Leonardo Morsut University of Southern California