Biomaterials and Biomolecular Constructs
Emphasis is on engineering functionality and issues surrounding biocompatibility of biomaterials and biomolecular constructs. Function could be derived from the static or dynamic properties of materials and based on biochemical, electromagnetic, mechanical, and/or tribological properties, for example.
The biomaterials and biomolecular constructs may be engineered to further enable technologies that are relevant to other NIBIB-supported program areas including but not limited to:
- plasmonic transducers (Biosensors and Physiological Detectors program)
- transmembrane CARs for T-cell control (Engineered Cells)
- magnetically-driven nanoparticles (Image-Guided Interventions program)
- coatings to tune the foreign body response, energy harvesters to power devices (Therapeutic Medical Devices program)
- tissue sealants (Surgical Tools program)
- scaffolds, hydrogels, bioinks (Engineered Tissues program)
The biomaterials and biomolecular constructs may be components of control systems, such as:
- delivery vehicles (liposomes, DNA nanoparticles, virus-like particles, metallic nanoparticles, micelles, dendrimers, etc.) for the targeted control of active agents
- surface-modified substrates for microfluidic platforms
- toehold switches for synthetic genetic circuits
- nucleases for genome editing machinery
Furthermore, this program supports the development of control systems (e.g., genome editing machinery, synthetic genetic circuits, microfluidics, etc.) designed to engineer biomaterials and biomolecular constructs.
Lastly, this program supports the development of analytical tools to interrogate biomaterials and biomolecular constructs as related to their design, development, and initial validation.
The development of imaging probes is supported by the NIBIB Molecular Probes and Imaging Agents program.
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Tissue development is guided by gradients of biomolecules that direct the growth, migration, and differentiation of cells. Biomedical engineers are interested in recreating these developmental gradients in adults to aid the growth of new tissue in areas that have sustained damage. This video shows the creation of a new 3D-printed scaffold that enables researchers to release biomolecules into the body with exceptional control.
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