Biomaterials and Biomolecular Constructs

This program supports the development of biomaterials and biomolecular constructs to elicit a broadly applied biomedically relevant effect across a spectrum of diagnostic, therapeutic, imaging, and interventional applications.


Emphasis is on engineering functionality and issues surrounding biocompatibility of biomaterials and biomolecular constructs. Function could be derived from the static or dynamic properties of materials and based on biochemical, electromagnetic, mechanical, and/or tribological properties, for example.

Additional emphasis

The biomaterials and biomolecular constructs may be engineered to further enable technologies that are relevant to other NIBIB-supported program areas including but not limited to:

The biomaterials and biomolecular constructs may be components of control systems, such as:

  • delivery vehicles (liposomes, DNA nanoparticles, virus-like particles, metallic nanoparticles, micelles, dendrimers, etc.) for the targeted control of active agents
  • surface-modified substrates for microfluidic platforms
  • toehold switches for synthetic genetic circuits
  • nucleases for genome editing machinery

Furthermore, this program supports the development of control systems (e.g., genome editing machinery, synthetic genetic circuits, microfluidics, etc.) designed to engineer biomaterials and biomolecular constructs.

Lastly, this program supports the development of analytical tools to interrogate biomaterials and biomolecular constructs as related to their design, development, and initial validation.


The development of imaging probes is supported by the NIBIB Molecular Probes and Imaging Agents program.