This program supports the development of engineered cells to elicit a broadly applied biomedically relevant effect across a spectrum of diagnostic, therapeutic, imaging, and interventional applications.
Emphasis is on engineering functionality and issues surrounding biocompatibility of engineered cells. Functionality could be derived from controlling natural or artificial attributes of an engineered cell and based on biochemical, optical, and/or mechanical properties, for example.
The cells may be engineered to further enable technologies that are relevant to other NIBIB-supported program areas, including but not limited to:
- bacteria for biomarker detection (Biosensors and Physiological Detectors program)
- drug-loaded, magnetically-driven bacteria (Image-Guided Interventions program)
The engineered cells may be components of control systems, such as:
- megakaryocytes for the production of designer platelets
- T-cells for targeted and on-demand delivery of active agents
Furthermore, this program supports the development of control systems (e.g., synthetic genetic circuits, microfluidics, etc.) designed to engineer cells.
Lastly, this program supports the development of analytical tools to interrogate engineered cells as related to their design, development, and initial validation.
Inquiries regarding the development of non-biological control systems and analytical tools should be directed to Dr. Šeila Selimović, and remaining inquiries about engineered cells should be directed to Dr. David Rampulla.