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Synthetic Biological Systems

This program supports the development and demonstration of synthetic biological systems. These modular platform technologies are designed to manipulate and interface with biology to enable new paradigms of clinical intervention for human health.

Emphasis

This program focuses on engineering new prototype synthetic biological systems to sense and actuate in response to human biology for clinical purposes. These technologies are biological chassis and biomimetic machines designed to be closed-loop systems to regulate cellular and tissue functions. Additionally, this program focuses on engineering new prototype parts and modules, such as the sensors and actuators that comprise synthetic biological systems. Projects should be directed toward overcoming a technological challenge that limits biomedical adoption. This program encourages projects that use a design-build-test approach.

Examples of technologies include but are not limited to:

  • synthetic genetic circuits for cellular control and decision-making
  • bacteria to regulate the microbiome
  • T-cells to target and eliminate infectious disease
  • organoid-based devices to replace tissue function
  • artificial cells to deliver therapeutics agents
  • molecular switches for synthetic genetic circuits
  • transmembrane CARs for T-cells
  • disordered protein compartments for intracellular communication

Additional Emphasis

Furthermore, this program focus on the discovery of design principles as key components in the design, build, and test methodology to engineer relevant synthetic biological systems.

 
Grant Number Project Title Principal Investigator Institution
1-DP2-EB028110-01 Novel nanoscale approaches to whole tissue reprogramming Daniel Gallego-Perez Ohio State University
1-R01-EB031936-01 Semi-synthetic, magneto-photonic circuit for non-invasive control of cellular function Ute Hochgeschwender Central Michigan University
1-R13-EB032256-01 8th International Conference on Stem Cell Engineering 2021 Izabela Balicka American Institute of Chemical Engineers
1-R21-EB031306-01 Selectively Replicating Trojan Virus Vectors as Programmable CRISPR-Based Antiviral Therapies Michael Phelps Washington State University
1-R21-EB030769-01A1 Engineering Probiotics to Sense and Respond to the Intracellular Redox Imbalance towards Mitochondrial Dysfunction Jiahe Li Northeastern University
1-R13-EB033176-01 Engineering Multi-Cellular Living Systems Thale Jarvis Keystone Symposia
1-R13-EB033184-01 2022 Bioinspired Materials Gordon Research Conference and Gordon Research Seminar Daniel Hammer Gordon Research Conferences
5-R21-EB030036-02 Development of a "Cell Splicing" Technology Platform Joshua Doloff Johns Hopkins University
5-R01-EB028782-02 Genetic-engineered control of the immunogeneic state of vascular composite allografts during preservation Korkut Uygun Massachusetts General Hospital
1-R01-EB031992-01A1 SMART BIOELECTRONIC IMPLANTS FOR CONTROLLED DELIVERY OF THERAPEUTIC PROTEINS IN VIVO AND ITS APPLICATION IN LONG-TERM TREATMENT OF HEMOPHILIA A Daniel Anderson Massachusetts Institute of Technology