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Synthetic Biological Systems

This program supports the design, development, and demonstration of synthetic biological systems technologies for biomedical intervention.

See NIBIB's response to COVID-19


Emphasis

This program focuses on engineering synthetic biological systems to sense and actuate in response to human biology for biomedical intervention. Projects should be directed toward overcoming a technological challenge that limits biomedical adoption. This program encourages projects that use a design-build-test approach.

Examples of synthetic biological systems include but are not limited to:

  • synthetic genetic circuits for cellular control and decision-making
  • bacteria to regulate the microbiome
  • T-cells to target and eliminate infectious disease
  • platelets to deliver therapeutic agents
  • organoid-based devices to replace tissue function

Additional Emphasis

Furthermore, this program focuses on the development of mathematical and computational methods, the development of screening and processing tools, and the discovery of design principles to design, build, and test engineered synthetic biological systems.