David Rampulla
Ph.D.
Director – Division of Discovery Science and Technology
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Synthetic Biology for Technology Development
This program supports the development of tools to enable synthetic biology approaches and the use of synthetic biology to develop technologies relevant to NIBIB-supported program areas.
Emphasis
Emphasis is on the design and wholesale construction of new biological parts and systems and the re-design of existing, natural biological systems for tailored purposes.
Additional emphasis
Examples of tools to enable synthetic biology approaches include but are not limited to:
- synthetic biological circuits for control and decision-making (Biomaterials and Biomolecular Constructs program, Engineered Cells program, Engineered Tissues program)
- design and evolution systems to construct biomolecules and biological systems (Biomaterials and Biomolecular Constructs, Engineered Cells program)
- advanced genome editing machinery for DNA manipulation (Biomaterials and Biomolecular Constructs program)
Examples of the use of synthetic biology approaches to develop technologies that are relevant to other NIBIB-supported program areas include but are not limited to:
- synthesis of biomaterials (Biomaterials and Biomolecular Constructs program)
- spatiotemporal control of tissue growth (Engineered Tissues program)
- selective detection of biomarkers (Bioanalytical Sensors program)
- regulated, on-demand delivery of therapeutic agents (Engineered Cells program)
- molecular imaging of cellular function (Molecular Imaging program)
Notes
Inquiries and applications are managed by the Synthetic Biology for Technology Development program, and awarded grants are managed in their relevant NIBIB programs.
| Grant Number | Project Title | Principal Investigator | Institution |
|---|---|---|---|
| 1-K99-EB027723-01 | Synthetic DNA-free circuits for “scarless” programming of mammalian cells | Xiaojing Gao | California Institute of Technology |
| 1-R21-EB026617-01A1 | Model Driven Construction of Dual-switch Selection Gene Drives to Combat Drug Resistance | Justin Pritchard | Pennsylvania State University-Univ Park |
| 1-R01-EB028320-01 | Programmable Synthetic Organelles Built from Disordered Proteins for Cellular Engineering | Matthew Good | University of Pennsylvania |
| 1-R01-EB028532-01 | Integration of systems and synthetic biology to advance development of human tissues ex vivo | Mo Ebrahimkhani | University of Pittsburgh at Pittsburgh |
| 1-R56-EB027729-01A1 | Engineering a smart CAR platform for human regulatory T cells | Wilson Wong | Boston University (Charles River Campus) |
Harvard's Base Editor uses modified CRISPR technology to selectively modify single base pair in DNA.