Grantee News

Marking a major milestone on the path to meeting the objectives of the NIH BRAIN initiative, researchers advance high-density electroencephalography (EEG) as the future paradigm for dynamic functional neuroimaging.

Researchers have used an ultrasound technique they pioneered a decade ago -- electromechanical wave imaging (EWI) -- to accurately localize atrial and ventricular cardiac arrhythmias in adult patients in a double-blinded clinical study. They evaluated the accuracy of EWI for localization of various arrhythmias in all four chambers of the heart prior to catheter ablation: the results showed that EWI correctly predicted 96% of arrhythmia locations as compared with 71% for 12-lead ECGs.

Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and 'second generation' approaches are needed. Now, a team of engineers may have a way to predict which mutations will occur in people, creating an easier path to create effective pharmaceuticals.

Biological engineers have created a multitissue model that lets them study the relationships between different organs and the immune system on a microfluidic chip seeded with human cells. With this 'organs-on-a-chip' model, they could explore the role of immune cells in ulcerative colitis and other inflammatory diseases.

With the help of photolithography and programmable DNA, researchers have created a new technique that can rapidly 'print' two-dimensional arrays of cells and proteins that mimic a wide variety of cellular environments in the body. This technique could help scientists develop a better understanding of the complex cell-to-cell messaging that dictates a cell's final fate.

Ranu Jung designs neural engineering projects that drive the process of transforming basic discoveries into clinical applications. In this interview she explains how collaborative projects can at once advance the understanding of the brain and the development of medical devices.

NIH has granted Sandia $6 million to build the prototype medical device that would make magnetoencephalography (MEG) — a type of noninvasive brain scan — more comfortable, more accessible and potentially more accurate.

Engineers have created a tabletop device that combines a robot, artificial intelligence and near-infrared and ultrasound imaging to draw blood or insert catheters to deliver fluids and drugs. Their research results suggest that autonomous systems like the image-guided robotic device could outperform people on some complex medical tasks.

Scientists report they have designed and successfully tested an experimental, super small package able to deliver molecular signals that tag implanted human cancer cells in mice and make them visible for destruction by the animals' immune systems. The new method was developed, say the researchers, to deliver an immune system 'uncloaking' device directly to cancer cells.

A team created an adaptable, wearable and stretchable fabric embroidered with conductive threads that provides excellent signal-to-noise ratio for enhanced MRI scanning.