Hybrid microscope could bring digital biopsy to the clinic

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By adding infrared capability to the ubiquitous, standard optical microscope, researchers hope to bring cancer diagnosis into the digital era. Pairing infrared measurements with high-resolution optical images and machine learning algorithms, the researchers created digital biopsies that closely correlated with traditional pathology techniques and also outperformed state-of-the-art infrared microscopes.

Tosato - DiPrima - 2020

The laboratory is focused on the study of cancer and the development of new and improved treatments for currently incurable cancers. The current project is focused on colorectal cancer, a leading cause of cancer death. Recently, we have discovered a vulnerability of colorectal cancer cells and exploited this discovery to develop two experimental drugs that effectively induce cell death in colorectal cancer cells. Briefly, Eph receptors are a family of tyrosine kinase cell surface receptors expressed in colorectal cancer cells.

Tanner - 2020

The Tanner lab is focused on the early stages of metastasis, when one or a few cells have migrated from the primary tumor and survived transport in blood and lymph vessels to colonize distant organs. In the field of mechanobiology, mechanical properties have been shown to modulate gene expression and phenotype and thus influence cell fate decisions.