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Optical Imaging and Spectroscopy

This program supports the development and application of optical imaging, microscopy, and spectroscopy techniques for improving disease prevention, diagnosis, and treatment in the medical office, at the bedside, or in the operating room.

Emphasis

The emphasis is on development of cost effective, portable, safe, and non-invasive or minimally invasive devices, systems, and technologies for early detection, diagnosis, and treatment for a range of diseases and health conditions.

Program priorities and areas of interest

The supported research and development areas include:

  • fluorescence imaging
  • bioluminescence imaging
  • optical coherence tomography (OCT)
  • second harmonic generation (SHG)
  • infrared (IR) imaging
  • diffuse optical tomography
  • optical microscopy and spectroscopy
  • confocal microscopy
  • multiphoton microscopy
  • raman imaging

Additional support

This program also supports:

  • early-stage validation of tools and devices
  • development of innovative light sources and fiber optic imaging devices
  • multimodal imaging
 
Grant Number Project Title Principal Investigator Institution
1-DP2-EB028111-01 HIGHLY MULTIPLEXED NANOSCALE IMAGING PLATFORMS FOR PROFILING AND INTERROGATION OF COMPLEX DISEASES Yongxin Zhao Carnegie-Mellon University
5-R01-EB026998-02 Next-generation optical brain functional imaging platform Qianqian Fang Northeastern University
5-K25-EB024595-04 Blood flow-based guidance and diagnostics using OCT Nestor Uribe-Patarroyo Massachusetts General Hospital
1-R21-EB029139-01A1 Novel Multi-Depth Two-Photon Microscope for Measuring Neuronal Network Plasticity Matthew Shtrahman University of California, San Diego
1-R43-EB029269-01A1 Blood Flow Imaging for Minimally Invasive Surgeryhttps://apps.era.nih.gov/grantfolder/viewInternalGF.era?applId=10008550 Abhishek Rege Vasoptic Medical, Inc.
5-DP1-EB024242-05 Massive wavelength-division multiplexing and imaging with laser particles Seok-Hyun Yun Massachusetts General Hospital
1-R15-EB025585-01A1 Volumetric Temporal Focusing Microscopy for Fluorescence-Guided Surgery Michael Durst Middlebury College
1-R43-EB030894-01 Cryo-correlative light and electron microscopy (cryo-CLEM) transfer holder for high-resolution imaging Khim Karki Hummingbird Precision Machine Company
1-R43-EB030979-01 A wide-field, high-resolution 3D exoscope for improved microsurgery workflow Mark Harfouche Ramona Optics, Inc.
5-R01-EB026705-04 Development of a fast scanning, extended field-of-view multiphoton microscope for clinical skin imaging Mihaela Balu University of California-Irvine