1. Research Funding
  2. Optical Imaging and Spectroscopy

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Optical Imaging and Spectroscopy

This program supports the development and application of optical imaging, microscopy, and spectroscopy techniques for improving disease prevention, diagnosis, and treatment in the medical office, at the bedside, or in the operating room.

Emphasis

The emphasis is on development of cost effective, portable, safe, and non-invasive or minimally invasive devices, systems, and technologies for early detection, diagnosis, and treatment for a range of diseases and health conditions.

Program priorities and areas of interest

The supported research and development areas include:

  • fluorescence imaging
  • bioluminescence imaging
  • optical coherence tomography (OCT)
  • second harmonic generation (SHG)
  • infrared (IR) imaging
  • diffuse optical tomography
  • optical microscopy and spectroscopy
  • confocal microscopy
  • multiphoton microscopy
  • raman imaging

Additional support

This program also supports:

  • early-stage validation of tools and devices
  • development of innovative light sources and fiber optic imaging devices
  • multimodal imaging
 

Funded Projects

Grant Number Project Title Principal Investigator Institution
1-DP2-EB028111-01 HIGHLY MULTIPLEXED NANOSCALE IMAGING PLATFORMS FOR PROFILING AND INTERROGATION OF COMPLEX DISEASES Yongxin Zhao Carnegie-Mellon University
5-R21-EB026762-03 All optical in vivo cardiac electrophysiology at cellular resolution Aaron Aguirre Massachusetts General Hospital
1-R21-EB029139-01A1 Novel Multi-Depth Two-Photon Microscope for Measuring Neuronal Network Plasticity Matthew Shtrahman University of California, San Diego
1-R15-EB025585-01A1 Volumetric Temporal Focusing Microscopy for Fluorescence-Guided Surgery Michael Durst Middlebury College
5-U01-EB027005-04 Wireless High-Density Diffuse Optical Tomography for Decoding Brain Activity Joseph Culver Washington University
1-R21-EB031261-01 Development of a platform to non-invasively assess microvascular endothelial dysfunction at the bedside in COVID-19 patients throughout intensive care. David Busch Ut Southwestern Medical Center
5-R01-EB025209-05 High throughput optical coherence tomography (OCT)-based imaging platform for label-free, non-invasive characterization of 3D tumor spheroids. Chao Zhou Washington University
5-R01-EB025173-04 Endoscopic Fine-Needle Polarized Scanning Spectroscopy for Pancreatic Cystic Lesions Diagnosis Lev Perelman Beth Israel Deaconess Medical Center
1-R01-EB030558-01A1 Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy Zhongping Chen University of California-Irvine
1-R21-EB031374-01 A Feasibility Study of a High-Throughput Live-Cell Microscopy Design for Visualizing Viral Particle Action and Nano-Carrier Delivery Performance Haw Yang Princeton University