Optical Imaging and Spectroscopy
The emphasis is on development of cost effective, portable, safe, and non-invasive or minimally invasive devices, systems, and technologies for early detection, diagnosis, and treatment for a range of diseases and health conditions.
Program priorities and areas of interest
The supported research and development areas include:
- fluorescence imaging
- bioluminescence imaging
- optical coherence tomography (OCT)
- second harmonic generation (SHG)
- infrared (IR) imaging
- diffuse optical tomography
- optical microscopy and spectroscopy
- confocal microscopy
- multiphoton microscopy
This program also supports:
- early-stage validation of tools and devices
- development of innovative light sources and fiber optic imaging devices
- multimodal imaging
Using a new type of microscopy developed in the High Resolution Optical Imaging lab at the National Institute of Biomedical Imaging and Bioengineering, researcher Hari Shroff is able to view individual blood cells moving through a live zebra fish embryo.
Here, C. elegans neurons grow throughout the worm as it develops. The striking difference can clearly be seen between the traditional, single-view iSPIM and the new dual-view iSPIM, recently developed by NIBIB researcher Dr. Hari Shroff.
Instant SIM imaging of the endoplasmic reticulum at 100 Hz over 200 time points. The instant SIM is able to take images at 100 frames per second. While there are conventional microscopes that are able to take images at this rate, they lack the resolution to show the fine features of the cell organelles.
A view through Dr. Hari Shroff's diSPIM microscope as it looks at a cell on a coverslip.