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Optical Imaging and Spectroscopy

This program supports the development and application of optical imaging, microscopy, and spectroscopy techniques for improving disease prevention, diagnosis, and treatment in the medical office, at the bedside, or in the operating room.

Emphasis

The emphasis is on development of cost effective, portable, safe, and non-invasive or minimally invasive devices, systems, and technologies for early detection, diagnosis, and treatment for a range of diseases and health conditions.

Program priorities and areas of interest

The supported research and development areas include:

  • fluorescence imaging
  • bioluminescence imaging
  • optical coherence tomography (OCT)
  • second harmonic generation (SHG)
  • infrared (IR) imaging
  • diffuse optical tomography
  • optical microscopy and spectroscopy
  • confocal microscopy
  • multiphoton microscopy
  • raman imaging

Additional support

This program also supports:

  • early-stage validation of tools and devices
  • development of innovative light sources and fiber optic imaging devices
  • multimodal imaging
 
Grant Number Project Title Principal Investigator Institution
1-DP2-EB028111-01 HIGHLY MULTIPLEXED NANOSCALE IMAGING PLATFORMS FOR PROFILING AND INTERROGATION OF COMPLEX DISEASES Yongxin Zhao Carnegie-Mellon University
5-R21-EB025389-02 Unrestricted super-resolution imaging deep in tissues through scattering immune spatial frequency modulated imaging Randy Bartels Colorado State University
5-R00-EB020749-05 Stimulated Raman imaging for label-free histology to guide brain tumor surgery Fake Lu State University of Ny,Binghamton
5-R01-EB026998-02 Next-generation optical brain functional imaging platform Qianqian Fang Northeastern University
5-R01-EB025145-02 Gated Diffuse Correlation Spectroscopy for functional imaging of the human brain Maria Franceschini Massachusetts General Hospital
5-R01-EB025673-03 A swallowed-capsule optical screening tool for histological assessment of the esophagus Irving Bigio Boston University (Charles River Campus)
5-R01-EB022077-04 In Vivo Laser Capture Microdissection Guillermo Tearney Massachusetts General Hospital
5-R01-EB027653-02 Development of stimulated Brillouin microscopy for high-resolution stiffness measurement Seok-Hyun Yun Massachusetts General Hospital
5-R03-EB028017-02 A dual-modality quantitative phase and polarized light microscope to assess cell motility and extracellular matrix remodeling during invasion Christopher Raub Catholic University of America
5-R21-EB028626-02 Acousto-optic modulated interferometric DCS (iDCS) operating at 1064 nm Maria Franceschini Massachusetts General Hospital