Technologies for Tissue Chips

This program supports the development of technologies to enable the engineering of tissue chips/microphysiological systems for biomedical applications.


Emphasis is on the design and construction of in vitro tools for analyzing and controlling the function of engineered human tissues. Examples include but are not limited to:

  • microfluidics to control spatiotemporal tissue growth
  • 3D bioprinting systems for tissue assembly
  • high-throughput assays and instruments to reduce the cost, time, and complexity of tissue engineering
  • bioreactors to produce tissues at scale

Further emphasis is on the development of tissue chips through the incorporation of technologies that are related to NIBIB-supported program areas, such as Bioanalytical Sensors and Biomaterials and Biomolecular Constructs.


The development of engineered tissue for regenerative medicine applications is supported by the NIBIB Engineered Tissues program.

Grant Number Project Title Principal Investigator Institution
5-R21-EB024889-02 Engineered Airway Construct for Cystic Fibrosis Disease Modeling Laura Niklason Yale University
5-R01-EB025256-02 Programmed Differentiation Circuits for Organoids using Meso-Microfluidics Ron Weiss Massachusetts Institute of Technology
5-R01-EB021908-04 GuMI: New In Vitro Platforms to Parse the Human Gut Epithelial-Microbiome-Immune Axis Rebecca Carrier Northeastern University
1-R01-EB027660-01 An Engineered Tissue Model of Aged Mammary Microenvironment Pinar Zorlutuna University of Notre Dame
5-R01-EB000244-40 A new high-throughput gastrointestinal tract explant platform for drug formulation discovery and metabolic disease modulation Robert Langer Massachusetts Institute of Technology
5-R21-EB025270-02 Multiscale Stereolithogrphic Bioprinting of Stage-Matching Vascularized Tumor Models Yu Zhang Brigham And Women'S Hospital
5-R21-EB025406-02 Engineered Glioblastoma Tumor Immunity for Personalized Immunotherapy Weiqiang Chen New York University
5-UG3-EB028094-02 A Human iPSC-based 3D Microphysiological System for Modeling Cardiac Dysfunction in Microgravity Deok-Ho Kim University of Washington
8-U01-EB029374-02 Human microtissues for in situ detection and functional measurement of adverse consequences caused by genome editing Todd Mcdevitt J. David Gladstone Institutes
8-U01-EB029371-02 Single Cell Profiling To Define Biomarkers Of Photoreceptor Dysfunction After Gene Editing Within PSC-Derived Organoids Krishanu Saha University of Wisconsin-Madison