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Technologies for Tissue Chips

This program supports the development of technologies to enable the engineering of tissue chips/microphysiological systems for biomedical applications.


Emphasis is on the design and construction of in vitro tools for analyzing and controlling the function of engineered human tissues. Examples include but are not limited to:

  • microfluidics to control spatiotemporal tissue growth
  • 3D bioprinting systems for tissue assembly
  • high-throughput assays and instruments to reduce the cost, time, and complexity of tissue engineering
  • bioreactors to produce tissues at scale

Further emphasis is on the development of tissue chips through the incorporation of technologies that are related to NIBIB-supported program areas, such as Biosensors and Physiological Detectors and Biomaterials and Biomolecular Constructs.


The development of engineered tissue for regenerative medicine applications is supported by the NIBIB Engineered Tissues program.

Register for one-hour Program Pointers webinars, here.

Grant Number Project Title Principal Investigator Institution
5-R21-EB025534-02 Establishing Mechanisms of Human Proximal Tubule Regeneration in an Engineered Organ on Chip Platform Megan Mccain University of Southern California
1-R21-EB025406-01A1 Engineered Glioblastoma Tumor Immunity for Personalized Immunotherapy Weiqiang Chen New York University
1-R21-EB025270-01A1 Multiscale Stereolithogrphic Bioprinting of Stage-Matching Vascularized Tumor Models Yu Zhang Brigham And Women'S Hospital
5-R21-EB025395-02 Engineering a Humanized Gut-Enteric-Axis Abigail Koppes Northeastern University
1-R21-EB025945-01A1 An artery-on-a-chip system containing blood outgrowth endothelium as a model of vaso-occlusion and drug testing in sickle cell disease Abhishek Jain Texas Engineering Experiment Station
5-R44-EB021704-03 he 3D Platelet Bank: A Clinical-grade, Scalable, 3D Microbioreactor Bone Marrow Mimetic for Platelet Production Teresa Desrochers Kiyatec, Inc.
5-UG3-EB025765-02 Multi-tissue platform for modeling systemic pathologies Gordana Vunjak-Novakovic Columbia University Health Sciences
1-UG3-EB028094-01 A Human iPSC-based 3D Microphysiological System for Modeling Cardiac Dysfunction in Microgravity Deok-Ho Kim University of Washington
5-R21-EB023573-02 Morphogenetic Self-Assembly of Human Heart Organoids David Sachs Icahn School of Medicine at Mount Sinai
5-R21-EB019508-02 Development of Complex Culture Systems to Study Valvular Dysfunction Kristyn Masters University of Wisconsin-Madison